Endocrine Abstracts

Introduction: Pheochromocytoma occurs in 50% of patients with multiple endocrine neoplasia syndrome type 2A (MEN2A). It is characterized by bilateral location, production of large amounts of adrenalin and a benign course, extraadrenal location being rare. Diagnosis is achieved by measuring catecholamines and metanephrines in serum or urine and/or through imaging techniques, including CT, MRI and 123I-MIBG scintigraphy.Objective: To describe clinical feat...

Background: There are no data concerning a relationship between alcohol and bone status of elderly Spanish men. Previous studies in other countries on the influence of alcohol intake on bone mineral density (BMD) in men are inconsistent and the effect of these variables on BMD is yet to be explored.Objective: The aim of this study was to describe the associations between total and beverage-specific alcohol intake and both BMD and bone ultrasound in elder...

Introduction: Cinacalcet is an oral calcimimetic indicated in treatment of primary hyperparathyroidism if patients do not accept surgery, do not carry out the surgical criteria, there is failure of previous surgery or serious comorbidity that makes surgery impossible.Methods: Descriptive study that included 34 patients with primary hyperparathyroidism treated with cinacalcet. We recorded clinical and biochemical data before and after 6 months of treateme...

Objective: To evaluate the effects of GH on cardiac structure and function of patients with panhypopituitarism.Material and methods: We performed echocardiographic studies of patients with panhypopituitarism treated and not treated with GH at baseline and after 12 years of follow up. We collected clinical and echocardiographic data (systolic and diastolic ventricular diameter (LVEDD and DTSVI), interventricular septum thickness (IVS), left ventricular po...

The Liver X Receptor (LXR) agonists have been shown to influence the development of hyperlipidemia and atherosclerosis in mouse models. It has also been demonstrated that some LXR agonists can cause hepatic steatosis in experimental animals. GH is also known to regulate hepatic metabolism and absence of the hepatic GH receptors leads to hepatic steatosis. In this study we analyzed whether actions of LXR agonists could involve interference with GH signaling. We showed that LXR ...

Introduction: Reference ranges for classifying a patient as hyper-, normo- and hypothyroidism vary from one laboratory to another, because the techniques used, regional factors (race, iodine..), but there is also the variables of age and sex of the patient are not taken. Article Thyroid Volume 21, Number 1, 2011, 5–11 Boucai et al, published equations to adjust the normal range in terms of these variables. Evaluate these equations and see if there are significant changes ...

Introduction: Functional GH deficiency has been described in fibromyalgia (FM). The efficacy of GH as add-on treatment has been suggested in small studies, but little is known in larger and homogeneous populations.Design: Patients (120) were enrolled in a multicenter, randomized, placebo-controlled trial for 18 months (NCT00933686). FM impact questionnaire (FIQ) >75 (severe), duration of FM >18 months, and stability of the standard therapy (amitr...

Objective: Our objective in this study was to identify the type of clinical care received by young type 1 diabetic patients who have made the transition from paediatric to adult care, and to assess the metabolic status of the patients. The research aimed to develop a sustainable and coordinated approach to facilitating the transition between diabetes services for adolescents and reveal from the perspective of the adolescents living with type 1 diabetes their experiences surrou...

Objectives: Our aim is to assess the cardiovascular risk factors that are already present at the time of diagnosing new-onset type 2 diabetes mellitus (DM).Materials and methods: This was an observational study. From each patient the following data were retrospective collected between January 2008 and September 2009: age, sex, DM in the family, smoking, HbA1c, hypertension (HTA) and dyslipidemia, microangiopathy and macroangiopathy, lipids and medical tr...

Pseudohypoparathyroidism (PHP) is a term applied to a heterogeneous group of disorders whose common feature is resistance to parathyroid hormone. Most of the PHP forms are caused by defects in GNAS: PHP-Ia (characterized by PTH and TSH resistance with Albright Hereditary Osteodystrophy) is caused by heterozygous inactivating mutations in those exons of GNAS encoding the α subunit of the stimulatory G-protein, and the autosomal dominant form of PHP-Ib (PTH an...